BIOIMMUNAS

Dietary supplement based on morinda citrifolia and 1,3-β-glucan with an immunomodulating and antioxidant action. Useful as an adjuvant in situations characterized by a reduction in immune defense and an increase in oxidative stress.
Morinda Citrifolia (Noni)
Equipped with numerous biological assets. The major components derived from the fruit and leaves include: terpenoids, flavonoids, linoleic acid, β sitosterol, scopoletin, ursolic acid, proxeranine.
1,3-β-Glucan (specific immunostimulant)
Polysaccharide that derives from brewer's yeast or from the wall of some species of fungi. It carries out a specific immunostimulating action because it binds to macrophages by means of a specific receptor, it also stimulates, activates and increases the production of T and B lymphocytes. not only an immune response but, by increasing the amount of cytokines, interleukins and other chemical mediators that promote the immune response, it determines an increase in tissue repair and has a protective action on the organism.
Vitamin E
Ubiquitous antioxidant at the level of cell membrane lipids and lipoproteins. Its main action is to protect cell membranes from oxidative damage and consists in blocking the hypoperoxidation chain reaction and therefore in limiting the propagation of oxidative damage triggered by free radicals on cells and tissues.
Ubiquinone (Coenzyme Q10, CoQ10)
Known for its mitochondrial energy production action, it prevents in turn the initiation and propagation of radical reactions generated by the peroxidation of polyunsaturated fatty acids (PUFA) at the level of the membranes and in the plasma helipoproteins, and is able to generate the vitamin E daltocopheryl- radical, supporting its antioxidant activity.
Vitis Vinifera
Source of the most powerful natural antioxidants (OPC: oligomeric procyanidins or polymeric catechins). These molecules acting on the hydro-lipid interface, with a possible role in the regeneration of both vitamin C (hydrophilic) and E (lipophilic), assist in tissue repair, in conditions of oxidative stress and potentiation of the immune defenses.
Polyphenols (Octocosanols from sugar cane)
A group of molecules characterized by the presence of hydroxyl groups linked to aromatic rings identified in many vegetables and fruits, with a defense role from UV rays and defense against pathogens.

Ingrediants
33.3 g 0.67 g 3.33 g

	per tablet of 1.5 g	per 100 g
Morinda Citrifolia (juice)	500 mg
Coenzyme Q10	10 mg
1,3 β-glucan from Saccharomyces cerevisiae 75%	10 mg	0.67 g
Vitamin E	10 mg	0.67 g
VitisVinifera> 95% OPC	100 mg	6.70 g
Octocosanols from sugar cane equal to Polyphenols	50 mg 7.5 mg
Other ingredients: fructose; sodium bicarbonate; acidifier (tartaric acid); natural flavors (forest fruit aroma, raspberry aroma).

How to use
1-2 tablets a day for 8-12 weeks or according to medical advice.

Warnings
Do not take during pregnancy.
Do not exceed the recommended daily dose.
Keep out of the reach of children under 3 years of age.
Supplements are not intended as a substitute for a varied diet.

storage
Store in a cool (<25 ° C) and dry place.
Variations in color and texture of the tablets do not compromise the quality of the product from a nutritional point of view when stored correctly.

Format
Carton with 2 blisters of 10 chewable tablets of 1500 mg. Net weight 30 g.

Bibliography
- Tan BK, Vanitha J. Immunomodulatory and antimicrobial effects of some traditional chinese medicinal herbs: a review. Curr Med Chem. 2004 Jun; 11 (11): 1423-30.
- Opara EI. The efficacy and safety of Chinese herbal medicines.Br J Nutr. 2004 Feb; 91 (2): 171-3. Review. No abstract available.
- Cimanga K, Hermans N, Apers S, Van Miert S, Van den Heuvel H, Claeys M, Pieters L, Vlietinck A. Complement-inhibiting iridoids from Morindamorindoides. J Nat Prod. 2003 Jan; 66 (1): 97-102.
- Sang S, Liu G, He K, Zhu N, Dong Z, Zheng Q, Rosen RT, Ho CT. New unusual iridoids from the leaves of noni (Morinda citrifolia L.) show inhibitoryeffect on ultraviolet B-induced transcriptional activator protein- 1 (AP-1) activity.Bioorg Med Chem. 2003 Jun 12; 11 (12): 2499-502.
- Bagchi D, Bagchi M, Stohs S, Ray SD, Sen CK, Preuss HG Cellular protection with proanthocyanidins derived from grape seeds. Ann NY Acad Sci. 2002 May; 957: 260-70. Revie.
- Wang MY, West BJ, Jensen CJ, Nowicki D, Su C, Palu AK, AndersonG. Morinda citrifolia (Noni): a literature review and recent advances in Noni research. Acta Pharmacol Sin. 2002 Dec; 23 (12): 1127-41.