Ecupharma

Melura Cist

Dietary supplement

Uro-Gynecological Area

Melura cist is a food supplement based on D-mannose, Pomegranate Extract and microencapsulated Lactobacillus plantarum LP01.

It is known that cystitis originates from intestinal bacteria due to the contiguity of colon-bladder tissues and the close proximity of the urethra outlet to the anus: factors favorable to the passage of bacteria into the urinary tract. Escherichia coli, a pathogenic saprophytic bacterium commonly present in the intestine, in case of alteration of the bacterial flora or irregularity of the intestinal transit, can multiply and go up to the bladder favoring the onset of urogenital infections.

E. coli , is able to form a biofilm which consists of the set of bacterial cells attached and incorporated in an adhesive polysaccharide matrix, secreted by the cells themselves. This happens when colonizing bacteria are not immediately separated from the surface and therefore can anchor more firmly using cell adhesion molecules, such as pili.

Bacteria have a defense system, referred to as quorum sensing, which allows them to remain invisible to the body's defense systems until they have reached a large and virulent population.

D-mannose is an isomer of glucose which, unlike this, once absorbed after ingestion, is not metabolized and is eliminated unchanged via the kidney.

D-mannose is characterized by a high ability to bind Escherichia coli, in particular it binds to fimbriae, structures necessary for bacteria to adhere to the walls of the urothelium, thus preventing their adhesion to the urinary mucosa.

The pomegranate fruit extract , which constitutes the polyphenolic complex contained in melura cist, has been used since ancient times in folk medicine for its properties. Several studies show that pomegranate extract is able to perform an effective activity of contrasting the motility of E. coli, thus reducing the ability of the bacterium to perpetrate the infection in the urinary tract. Furthermore, the polyphenolic complex is capable of inhibiting the formation of the biofilm of Escherichia coli thus interfering with its proliferation. In this way, once the biofilm is broken down thanks to the action of the polyphenols, the bacteria remain in suspension in the urine and are eliminated with the urinary stream.

Lactobacillus plantarum LP01 is a probiotic that favors the balance of the intestinal bacterial flora. Numerous scientific studies have shown that regular use of probiotics can help reduce or prevent certain unwanted conditions caused by pathogenic bacteria, including Escherichia coli. In vitro studies have shown that Lactobacillus plantarum LP01 inhibits the growth of E.coli. Melura cist contains two billion microencapsulated Lactobacillus plantarum LP01. Microencapsulation provides an effective barrier and allows probiotics to pass safely through the acidic environment of the stomach and reach the intestinal tract unaltered where they can express their biological activity.

Ingredients Dry extract of pomegranate tit. 70% in ellagic acid (250 mg), D-Mannose (2 g), microencapsulated Lactobacillus plantarum LP01 (≥2 billion cells), Vitamin B6 (0.7 mg)

Properties Adjuvant of urinary function. Melura cist provides a dose of D-mannose equal to 2 grams per sachet

How to use 1 sachet per day

Warnings As a precaution, it is recommended not to take during pharmacological treatments with oral anticoagulants (vitamin K antagonists, for example warfarin).

Pack of 10 sachets of 2.6 g