Description
HYALUBRIX 60 is a sterile viscoelastic solution produced with sodium hyaluronic acid obtained by bacterial fermentation from a high molecular weight fraction. Hyaluronic acid, a polysaccharide of the glycosaminoglycan family, is naturally present in many human tissues such as cartilage and synovial fluid; it is continuously secreted in the joint cavity and represents the major component of the synovial fluid, to which it supplies its characteristic viscosity and elasticity. These properties are fundamental for the fluid to perform the functions of lubricant and shock absorber in normal joints, in order to protect the cartilage and soft tissues from mechanical damage. In traumatic and degenerative diseases of the joints, the amount of hyaluronic acid decreases and the synovial fluid loses viscosity, causing impaired function and painful symptoms. Many literature data indicate that the intra-articular administration of hyaluronic acid is able to restore the viscoelastic properties of the synovial fluid, with a consequent attenuation of pain and an improvement in the mobility of the joint. HYALUBRIX 60 is a treatment for the temporary replacement of synovial fluid in patients suffering from degenerative or mechanical arthropathy of the knee and hip, which causes an alteration in the functional performance of the synovial fluid. The intra-articular injection of HYALUBRIX 60 reduces pain symptoms and improves joint function of the knee and hip for up to six months.
It is indicated for the treatment of pain and the improvement of joint function in patients with degenerative or mechanical arthropathy of the knee, hip, shoulder, ankle and trapeziometacarpal joint. The product is indicated in the treatment of persistent pain after initial failure of analgesics or in case of failure or intolerance to non-steroidal anti-inflammatory drugs.

Composition
Hyaluronic acid sodium salt 1.5%, sodium chloride, disodium hydrogen phosphate dodecahydrate, sodium dihydrogen phosphate dihydrate, water for injections.

How to use
The injection must be strictly intra-articular. The intra-articular injection should be performed according to the standard technique, using a precise anatomic location. In the hip, ultrasound or radioscopic guidance is recommended.
If there is a spill, remove it before administering the product.
All rules regarding asepsis and injection techniques must be observed.
Inject HYALUBRIX 60 using a suitable sterile needle (e.g. 18 or 20 G), into the affected joint.
After the first application, further treatments may be necessary to maintain the benefits of the treatment over time, depending on the needs of the individual patient.
Clinical data show that the efficacy of HYALUBRIX 60 persists for up to 6 months. An additional injection, if clinically required, should be given after this time.

Warnings
Do not administer to patients with ascertained individual sensitivity to the components of the product. Do not administer in case of skin infections or diseases in the injection area. Do not administer to patients with active synovitis. The safety and efficacy of HYALUBRIX in pregnant women, lactating women or in individuals below 18 years of age have not been established and therefore its use is contraindicated in these patient populations. Do not use if package is damaged. Do not use the product after the expiry date stated on the package. The expiry date refers to