Krymi Mannocist-D Food Supplement 20 Sachets

Mannocist D sachets

Mannocist D cystitis treatment

Mannocist-D sachets, based on D-Mannose, is a food supplement able to inhibit the adhesion of bacteria responsible for urinary tract infections at the level of the urethral and bladder epithelium, to favor their elimination through the urine and to limit hence the onset of infections. D-Mannose can be used both in acute urinary tract infections and in their relapses, thanks to the synergy of Mannocist-D with antibiotics and antimicrobials it can favor the functionality of the latter by increasing the patient's adherence to therapy.

Composition of Mannocist D Sachets

D-Mannose 1.5 g, sodium bicarbonate, sorbitol, silicon dioxide.

How is MANNOCIST D SACHETS taken?

If you are in an acute phase it is advisable for the first 3 days, 1 sachet in the morning and 1 in the afternoon with an empty stomach and bladder , while for a maintenance phase, 1 sachet every morning is enough, with an empty stomach and bladder, until total disappearance of symptoms. While in cases where sexual intercourse is the trigger of cystitis , you must take 1 sachet after each intercourse and 2 sachets in the following 24 hours, according to the methods described above. To take the product, just dissolve the contents of the sachet in half a glass of water at room temperature, then do not drink or eat for about 40 minutes, for the rest of the day drink plenty of water to help eliminate bacteria with urination.

Contraindications

Studies of cytotoxicity, sensitization and irritation of the oral mucosa found no contraindications.

Possible side effects

Meteorism can occur, which generally disappear after a few days.

Packaging

Mannocist D is sold in packs of 20 single-dose sachets of 2 g.

Main characteristics

1. - STRATEGY TO CONTRAST UTI (Urinary Tract Infection) ALTERNATIVE AND / OR SUPPORT TO ANTIBIOTIC AND ANTIMICROBIAL THERAPIES

1. - CLASS IIa MEDICAL DEVICE CERTIFIED BY INSTITUTE OF HIGHER DISHANITY

1. - D-MANNOSE 1.5 g FOR SINGLE DOSE

1. - NO CONTRAINDICATIONS FOR USE ACCORDING TO THE BIOCOMPATIBILITY TESTS CARRIED OUT

• - Cytotoxicity
• - Allergic sensitization
• -Iritation of the oral mucosa.

1. - FREE OF GLUTEN AND LACTOSE

1. - NICKEL TESTED Value found <0.1 ppm

• • D-Mannose

D-Mannose is a simple sugar, a hexose monosaccharide extracted from larch or birch wood with a high safety profile for use. It is rapidly absorbed from the intestine and in a short time (30 min) distributed in the blood and all organs ⁽¹⁾ . It cannot be converted into glycogen and therefore is not accumulated in the liver or other organs, nor is it used up by the body ⁽²⁾ . Excess mannose reaches the kidney and bladder and is eliminated in the urine. Long-term administration of mannose, in concentrations up to 20%, produced no effects on metabolism or signs of toxicity, which supports the good general toxicological profile ⁽³⁾ .

• • D-Mannose activity on bacteria

The adhesion of bacteria to the surface of animal cells is a crucial factor for virulence and the onset of infections. Often this recognition-adhesion is mediated by residues of sugars such as D-Mannose and L-fucose which bind specific allelectins of the bacterial surface. Different factors of virulence are known and described which are more and abundantly represented on pathogenic serotypes for example of E.coli (known as UPEC Uropathogenic Escherichia coli), of Salmonella and other bacteria involved in urinary tract infections such as Proteusmirabilis ^{(4) (5)} .

• • D-Mannose in the treatment of UTI

The bladder wall is lined with various mannosylated proteins, including Tamm-Horsfall (THP) proteins, which interfere with the adhesion of bacteria to the epithelium. THP binds to E. coli with a highly specific and saturable bond, which is inhibited by D-Mannose ⁽⁶⁾ suggesting an important role of THP mannosyltate groups in specific binding, in particular with pathogenic coli endowed with the virulence factor FimH, which more abundant are found in UTI patients than in the healthy population. D-Mannose mimics the functionality of the urothelial barrier, inhibiting the adhesion of bacteria to the epitheliourethral and bladder levels. Bacteria, by binding with the free D-Mannose molecules in the urine, rather than nesting in the mucosal walls, remain trapped in the urine stream and eliminated with it. In vitro and vivo studies have shown the ability of mannosides to reduce the bacterial load by 2 orders of magnitude in the urine and 4 in the bladder ⁽⁷⁾ .

• • Conclusions

There is a strong and consolidated scientific rationale regarding the efficacy of D-Mannose in inhibiting the adhesion of the bacteria responsible for UTI, in favoring bacterial clearance through the urine and therefore in reducing the onset of infections ^(8-10) . The nature of the monosaccharide and long-term studies support the fact that it is free from toxicity even if ingested at much higher doses than ordinary dietary ones ⁽³⁾ .

How to store Mannocist D sachets?

The product must be stored in its original packaging in a cool place away from sources of heat and humidity and from the reach of children.