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LITHOSOLV - Granular Potassium Citrate

Daily supplementation of alkalizing potassium salts to help restore and maintain the systemic and urinary acid-base balance

The changed dietary habits, linked to diets oriented to excessive intake of proteins or fats, tend to shift the metabolic balance of the organism towards an excessive acid load (1). This condition would facilitate, with its prolongation, the onset of some pathologies, such as osteoporosis and kidney stones (2), which often occur, precisely with a low presence of citrates in the urine and with an acidic urinary pH (5.0 -5.5). Maintaining these urinary acid values would more easily lead to the precipitation of uric acid present in the urine and the consequent formation of uric acid stones.

On the contrary, the correction of this state of acidosis with alkalizing elements would favor the dissolution and solubilization of urinary uric acid.
A diet rich in fruit and vegetables is the main source of alkalizing substances, designed to correct the excessive acid load (3).
The dietary approach alone is not always sufficient but a dietary supplement may be necessary. This occurs mainly in elderly subjects, in people who perform intense physical activity, in postmenopausal women or in subjects with diets strongly rich in proteins.

LITHOSOLV is a food supplement of alkaline potassium salts capable of correcting the excessive acid load, which can be directly evaluated by measuring the urinary pH; this can be easily done by using the strips attached to the LITHOSOLV * package.
The urinary pH is a value that varies throughout the day with more significant drops during the night and in the morning; for this reason it is preferable to measure it especially upon awakening. If the pH value is lower than 6 it is advisable, if confirmed by the doctor, to make any correction by taking LITHOSOLV * in the morning and in the evening, then verifying its urinary alkalizing action with the appropriate strips.
In the presence of uratic stones it is advisable to maintain the urinary pH between 6.5-6.8 to favor the dissolution of the uric acid crystals (4). A daily water intake of 2.5-3 liters is also recommended to favor the dilution of urinary auric acid (4).

Dosage:
Each measuring cup provides a quantity of potassium in the form of citrate and bicarbonate equal to 1.173 g of potassium (30 mEq).

Dosage and method of use:
The daily dosage of LITHOSOLV is usually 1 scoop taken on a full stomach preferably in the evening. The particular retard formulation of the powder allows a continuous release of alkalizing substances ensuring constant pH values throughout the day.
In the event that the urinary pH, measured in the morning upon awakening, is still lower than 6.0, it is advisable to take a second measuring cup after the morning coalition.

Pour the contents of a measuring cup into half a glass of water, mixing thoroughly; due to the lipophilic nature of the microgranules which guarantee the controlled release of the alkaline salts contained in them, a suspension will be formed which must be taken immediately. The insolubility of the micro granulate is therefore a peculiarity of the preparation and does not affect its absorption and effectiveness.

Contraindications and Precautions:
LITHOSOLV is contraindicated in patients suffering from hyperkalaemia or conditions that may predispose to the appearance of this plasma alteration. These conditions include chronic renal failure, uncontrolled diabetes mellitus.

Interactions:

The simultaneous intake of LITHOSOLV and potassium-sparing drugs (triamterene, spironolactone, amiloride) could cause hyperkalaemia. It is therefore advisable to monitor the progress of kalaemia. No interactions with other drugs are known.

Hypersensitivity and side effects:

LITHOSOLV is generally well tolerated. Rarely, in particularly sensitive individuals, mild gastrointestinal disturbances such as abdominal heaviness, nausea and occasionally diarrhea may develop.

Packaging:

153g bottle with 5.1g teaspoon of powder. Each bottle corresponds to approximately 30 doses of 5.1 g. Each cicchiaino contains 1.031 grams of Potassium Biocarbonate and 2.228 grams of Potassium Citrate for a total of 1.173 grams of Potassium ion (30 mEq). Inside the package there is a plastic sachet with 20 strips for pH control with relative colorimetric scale.

Using the pH strips:
Collect urine in a container. With dry hands, remove a strip from the transparent sachet.
Dip the strip into the urine second, pull it out and drain the excess urine.

The wet part of the strip will take on a different color depending on the pH of the urine.
Within 2 minutes, compare the color of the strip with that of the reference shade guide, present in the package. Read the value corresponding to the color that comes closest to that of the strip.

Disposable strips should be disposed of in household waste after use.
Note: any changes in the color of the unused strips do not affect their accuracy.