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LITHOSOLV PLUS - Potassium Citrate

Daily supplementation of alkalizing potassium salts to help restore and maintain the systemic and urinary acid-base balance.

The changed dietary habits, linked to diets oriented to excessive intake of proteins or fats, tend to shift the metabolic balance of the organism towards an excessive acid load (1). This condition would facilitate, with its prolongation, the onset of some pathologies, such as osteoporosis and kidney stones (2), which often occur, precisely with a low presence of citrates in the urine and with an acidic urinary pH (5.0 -5.5). The maintenance of these urinary acid values would more easily induce the precipitation of uric acid present in the urine and the consequent formation of uric acid stones. On the contrary, the correction of this state of acidosis with alkalizing elements would favor the dissolution and solubilization of urinary uric acid.

A diet rich in fruit and vegetables is the main source of alkalizing substances, designed to correct the excessive acid load (3).
The dietary approach alone is not always sufficient but a dietary supplement may be necessary. This occurs above all in elderly subjects, in people who perform intense physical activity, in postmenopausal women or in subjects with diets strongly rich in proteins.

LITHOSOLV PLUS tablets is a food supplement of alkaline potassium salts capable of correcting the excessive acid load, which can be directly evaluated by measuring the urinary pH; this can be easily done by using the strips attached to the LITHOSOLV PLUS tablet package.
The urinary pH is a value that varies throughout the day with more significant drops during the night and in the morning; for this reason it is preferable to measure it especially upon awakening. If the pH value is lower than 6 it is advisable, if confirmed by the doctor, to make any correction by taking LITHOSOLV tablets in the morning and in the evening, then verifying its urinary alkalizing action with the appropriate strips.
In the presence of uratic stones it is advisable to maintain the urinary pH between 6.5-6.8 to favor the dissolution of the uric acid crystals (4). A daily water intake of 2.5-3 liters is also recommended to facilitate the dilution of urinary uric acid (4).

DOSAGE
Each tablet contains 1.5g of potassium citrate, equal to 586.5 mg of Potassium (i.e. 15mEq), in a formulation that guarantees a prolonged release over time.

DOSAGE AND METHOD OF USE
The daily dosage of LITHOSOLV PLUS tablets is 2 tablets divided into two daily administrations (unless otherwise indicated by the doctor) taken on a full stomach. The particular retard formulation of the tablet allows a cootinuous release of alkalizing substances ensuring low pH values throughout the day.
In the event that the minimum pH, measured in the morning upon waking up, is still lower than 6.0, it is advisable to double the dosage reaching 4 daily tablets always divided into 2 doses.

CONTRAINDICATIONS and PRECAUTIONS
LITHOSOLV PLUS tablets are contraindicated in patients suffering from hyperkalaemia or from conditions that may predispose to the onset of such plasma alteration. Among these conditions are chronic renal insufficiency, uncontrolled diabetes mellitus.

INTERACTIONS
The simultaneous intake of LITHOSOLV PLUS tablets and potassium-sparing drugs (triamtereoe, spironolactone, amiloride) could deceive hyperkalaemia. It is therefore advisable to monitor the progress of kalaemia. There are no known interactions with other drugs.

HYPERSENSITIVITY AND UNDESIRABLE EFFECTS
LITHOSOL V PLUS tablets are generally well tolerated. Rarely, in particularly sensitive subjects, mild gastrointestinal disturbances such as abdominal heaviness, nausea and occasionally diarrhea may develop.

PACKAGING:
Bottle of 60 retard tablets
USE OF pH STRIPS
Collect urine in a container. With dry hands. take a strip from the transparent sachet. Immerse the strip in the urine for 1 second, remove it and drain the excess urine. The wet part of the strip will take on a different color depending on the pH of the urine. Within 2 minutes, I will see the color of the stripe and or that of the reference color guide, present in the package. Read the value corresponding to the color that comes closest to that of the strip.

Disposable strips should be disposed of in household waste after use.
Note: any changes in the color of the unused strips do not affect their accuracy.