MIOVEN
700

Dietary supplement based on diosmin, sweet orange (hesperidin), butcher's broom. MIOVEN 700 provides useful elements for the maintenance of the physiological venous circulation (functionality of the haemorrhoidal plexus) and for the physiological functionality of the microcirculation (heaviness of the legs).
Diosmin
It exerts a double action on the capacitance vessels: at the level of the veins and venules, it increases the parietal tone and exerts an anti-venous stasis action, while at the level of the microcirculation it increases the resistance of the capillaries and normalizes their impermeability, making them less fragile. The protective effect of diosmin against vascular damage is also expressed through the inhibition of the release of inflammation mediators (prostaglandins, free radicals, cytokines) by polymorphonuclear cells and macrophages ¹ .
Hesperidin
It reduces the excessive vascular permeability of capillaries and increases the resistance of the endothelium ² .
Rusco
Recommended for the treatment of problems associated with venous synchronic insufficiency, such as pain, heaviness, leg cramps, swelling and itching. ³ Ruscogenin activates microcirculation and preserves skin integrity through various mechanisms. Ruscogenin reduces cell impermeability, thanks to its anti-elastase activity. Elastase is an enzyme that degrades elastin, a major component of venous elastic fibers. Collagen and elastin are the main components of the extracellular matrix. The anti-elastase activity of ruscogenin avoids the degradation of the perivascular components and thus reduces cell permeability. The ruscogenic also possesses vasoconstrictive properties, through adrenergic mechanisms. ^4-5

Ingrediants
Diosmin; sweet orange (hesperidin); rusco.

How to use
2 tablets per day in the attack phase and 1 tablet per day in the maintenance and / or prevention phase.

Warnings
It can be taken by the diabetic, the celiac, the lactose intolerant. Do not exceed the recommended daily dose. Keep out of the reach of children under 3 years of age. The supplements are not intended as substitutes for a varied diet.

Format
20 tablets in blister pack.

Bibliography
- 1. Smith PD. Neutrophil activation and mediators of inflammationin chronic venous insufficiency. J Vasc Res 1999; 36: 24-36.
- 2. Manthey JA. Biological properties of flavonoidspertaining toinflammation. Microcirculation2000; 7: S29-S34.
- 3. Phytotherapy. Rational use of plant drugs, CapassoFrancesco, Giuliano Grandolini, Izzo Angelo A
- 4. Monograph Ruscus aculeatus (Butcher's Broom) Alternative Medicine Review Volume 6, Number 6. 2001.
- 5. Pharmacological assessment of adrenergic receptor in humanvaricose veins. Miller VM et al. Int. Angiol. 19: 176-183. 2000.