Description
Food supplement containing carcinin, anti-glycating, de-glycating and anti-aging.
Inhibition of the synergy between glycation and oxidation reactions.
Stopping scavenging propagators (glucose, glyoxal, etc.).
Inhibition of lipid peroxidation.
Chelation of metal ions.
Anti-aging skin treatment.
Use:
- internal medicine: metabolic syndrome, diabetic complications, obesity;
-gynecology: polycystic ovary syndrome (PCOS);
-dermatology: anti-aging (publication in Carcinina at the 24th World Congress of Dermatology-Milan 2019);
-Ophthalmology: cataracts, retinal degeneration.

Property
Carcinine is more stable than carnosine, it is not attacked by the carnosinase enzyme, nor is it converted to histidine. It is rapidly assimilated, resistant to gastric pH, skin, serum and tissue peptidases. It has a longer duration in the body, allowing to improve its effectiveness against the application.

Ingrediants
Glycoless (carcinin dichlorohydrate), Lithotame (Lithothamnion calcareum Areschoug) thallus powder, magnesium stearate, chromium picolinate, vegetable gelatin capsule (E171).

Nutritional characteristics
200 mg

Average values for 1 capsule
Glycoless
Lithotame	200 mg
Magnesium stearate	2 mg
Chromopicolinate	1.66 mg

How to use
1 capsule to be taken in the morning on an empty stomach.

storage
Store at a temperature not exceeding + 25 ° C.
Validity for intact packaging: 36 months.

Format
Pack of 15 capsules.

Cod. NOM

Bibliography
1. "The role of carcinine treatment on glycolipid imbalance of overweight and obesewoman", Palmieri B., Pepe V., Simas Law, Granzoti R., Novak B., Wolpe Re, ZilbertB., Yamaguchi Em, Vadalà M., Department of General Surgery and SurgicalSpecialties, University of Modena and Reggio Emilia Medical School, Surgical Clinic.
2. "A suplementação de carcinina and its implication na glycemiade jejum, hemoglobin glycade, insulin, frutosamine and perfil lipidico em mulherescom sobrepeso and obesidade: um ensaio clínico randomizado duplo-cego controlado porplacebo". Simas, AW; Granzoti; r .; Novak, b; wolpe, rE; Zilbert, b .; Yamaguchi, eM
3. "L-Carnosine (-alanyl-L-histidine) and carcinine F-alanylhistamine) act as naturalantioxidants with hydroxyl-radical-scavenging and lipid-peroxidase activities", Mark A. Babizhayev, Marie-Christine Seguin, Jean Gueynej, Rima P. Evstigneeva, Elena A. Ageyevaand Galina A. Zheltukhinai, Moscow Helmholtz Research Institute of Eye Diseases, Russia, and IM.V. Lomonosov Institute of Fine Chemical Technology, Russia, Exsymol SAM, Monaco, Principaute de Monaco.
4. "Carcinine Has 4-Hydroxynonenal Scavenging Property and Neuroprotective Effect inMouse Retina", Lea D. Marchette, Huaiwen Wang, Feng Li, Mark A. Babizhayev, AnneKasus-Jacobi, Departments of Ophthalmology, Molecular Biology Proteomics Facility, and Pharmaceutical Sciences, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma.
5. "Investigating Carcinine Transport and the Expression Profile of Transporter Genes inHuman Corneal Epithelial Cells", Studies on the Cornea and Lens, pp 131-144, AnneKasus-Jacobi (Department of Pharmaceutical Sciences and Oklahoma Center for Neuroscience), Vibudhuta Awasthi (Department of Pharmaceutical Sciences, University of Oklahoma Health Sciences), Mark A. Babizhayev (Innovative Vision Products Inc., Moscow, Russia), H. Anne Pereira (Departments of Pharmaceutical Sciences, Pathology, and CellBiology and Oklahoma Center for Neuroscience, University of Oklahoma Health SciencesCenter , Oklahoma City, USA).
6. "Treatment of Skin Aging and Photoaging with Innovative Oral Dosage Forms of Non-Hydrolized Carnosine and Carcinine", Research Article, International Journal of Clinical Dermatology & Research (IJCDR), Babizhayev Mark A. (Innovative Vision Products, Inc).
7. "Advanced Glycation End-Products and Their Receptor-Mediated Roles: Inflammation and Oxidative Stress", Parisa Younessi, Ali Yoonessi, Iran J Med Sci, September 2011; Vol 36N. 3.
8. A. Pegova, "Comp. Biochem. Physiol.", Vol. 127, (2000). pp. 443-446.