Orofer Medic Italia 40 Sachets

Orofer Medic Italia Food Supplement

Food supplement based on iron, vitamin C, folic acid, vitamin B12, zinc and copper, useful in case of lack of intake or increased need for these nutrients.

Gluten free.

Divalent iron fumarate

The human body contains about 3 - 4 g of iron in the form of hemi iron Fe2 + (iron ion) and non-hemi iron Fe3 + (ferric ion). The first is bound to the e group of proteins hemoglobin and myoglobin, and represents about 75% of the total iron present in the body (65% hemoglobin and 10% myoglobin). The remaining 20 - 25% of ferrototal is non-emic iron and is found in the spleen, liver and bone marrow, bound to ferritin and hemosiderin, with a storage function. A small amount of iron (0.1-0.5% of the total) is present in some intracellular enzymes and in transferrin, a glycoprotein that transfers it to the hemoglobin of the bone marrow. In this way the non-hemi iron is converted into hemi iron. Iron is necessary for the synthesis of hemoglobin (protein that carries oxygen to cells), myoglobin and collagen; it is also indispensable in the processes of cellular respiration and in the metabolism of nucleic acids. The daily iron requirement for men is 10 mg while for women 18 mg. Although present in many foods (meat, liver, legumes, shellfish, dried fruit and green vegetables), the lack of iron is still the most common mineral deficiency1. Those at risk of iron deficiency are: premature babies; infants, as milk, including maternal milk, is low in iron; pregnant women; women of childbearing age1 (iron loss due to the physiological cycle); people who have experienced blood loss; seniors; alcoholics; ivegetarians. The symptoms of iron deficiency are ¹ : asthenia, headache in the most severe cases, palpitations, neuralgia, vasomotor disturbances, ease of infections, iron-free anemia. A supplementation of divalent iron fumarate prevents iron deficiency anemia due to a diet deficient in this element or to other hepatological or physiological causes (monthly cycle). It increases resistance to stress and diseases, strengthens the immune system and increases energy production. Salification as fumarate increases its absorption and bioavailability.

Zinc

Zinc is an essential mineral for many biological functions such as: immune resistance, wound healing, digestion, reproduction, physical growth, diabetes control, taste and smell ² . More than 300 human body enzymes require zinc for proper function. It is estimated that 3,000 of the 100,000 proteins involved in human life contain this mineral ³ . It is stored mainly in the muscles, is also found in high concentrations in red and white blood cells, in the retina, bones, skin, kidneys, liver, pancreas and, in men, the prostate. Many cells secrete this mineral, including those of the pancreas, those of the prostate and the salivary glands. Its properties make zinc essential for correct body growth; its administration is therefore recommended during gestation and lactation and also in case of iron intake.

Copper

Copper is an essential metal for the growth and development of the human body. It is present in about 30 enzymes, in turn involved in various physiological functions, and is also contained in some proteins such as albumin and V coagulation farms. Copper is present in many foods such as: liver, shellfish, oysters, crabs, lobsters, lamb, duck, pork, beef, chocolate, walnuts, almonds, hazelnuts, sunflower seeds, soy, wheat germ, yeast, corn oil , margarine, mushrooms and bran. Once introduced with food, it is absorbed in the stomach and small intestine and, thanks to the bond with albumin, enters the bloodstream to reach the liver (the organ with the highest copper content), where hepatocytes in turn synthesize a complex consisting of copper and celuroplasmin which is then secreted to be distributed to the various tissues. The functions of copper are multiple: it is required for the formation and maintenance of myelin (the protective layer that covers neurons) ⁴ ; it is contained in enzymes that synthesize neurotransmitters (messengers that allow the transmission of signals through nerve cells) ^5,6 ; fights cellular oxidation by helping to eliminate free radicals (through the enzyme superoxide dismutase); influences cholesterol metabolism (reduces LDL and increases HDL); catalyzes the formation of melanin (a substance that protects the skin from sunlight, and prevents skin aging) ⁴ ; intervenes in the production of collagen and elastin (important for tendons and bones); participates in the processes of bone mineralization and the formation of new red blood cells. Copper has also been shown to be involved in the functionality of the immune system, and in fact copper deficiencies have significant repercussions on macrophages and neutrophils. Copper is essential for the use of vitamin C and facilitates the absorption of iron ^4,5 . Therefore its administration is also recommended in case of iron intake. During pregnancy copper is particularly necessary as the fetus is totally dependent on the mother for the needs of this mineral (0.05 mg / day). The infant, on the other hand, takes it through milk and, even if breast milk contains only 0.32 mg / liter, this quantity is better absorbed because it is more bioavailable than the copper present in infant formula (1-2 mg / liter).

C vitamin

Vitamin C, also known as ascorbic acid, is a water-soluble vitamin that is an essential part of life. It is commonly found in fresh fruit, particularly in the citrus family: oranges, lemons and mandarins. The body needs vitamin C for the formation and maintenance of bones, blood vessels and skin. This vitamin is perhaps the most popular of the common nutrients and, along with sodium, potassium and calcium salts, is commonly used as an antioxidant food additive. Vitamin C performs multiple functions, both as a coenzyme and as a cofactor. It is mainly involved in the biosynthesis of collagen (component of teeth, bones, gums, cartilage, vertebral discs, skin and blood vessels), it also participates in the iron absorption processes and, together with vitamin E, protects against oxidative damage and stimulates the production of antibodies , strengthening the immune system. Vitamin C is also needed for the synthesis of dopamine, noradrenaline and adrenaline in the nervous system and adrenal glands. It has been shown to be useful for: reducing total cholesterol, LDL, triglycerides, increasing HDL levels, lowering blood pressure and inhibiting platelet aggregation, thus protecting the cardiovascular system. Researchers have also highlighted the relationship between high blood levels of vitamin C and reduced risk of stroke ⁷ .

Folic acid

Folic acid (or folacin) is a water-soluble B vitamin necessary for all DNA synthesis, repair and methylation reactions, homocysteine metabolism and other important biochemical reactions, especially when intense periods of cell division are involved. of rapid growth. In fact, it promotes the normal formation and maturation of red blood cells, ensures the good functioning of the nervous system and the reproductive system and regulates the development of nerve cells. Additionally, pregnant women have an increased need for it ⁽⁸⁾ , both for themselves and their baby. Folic acid is required for proper cell differentiation and growth during fetal development and many studies have found a relationship between low levels of folic acid in the maternal blood and the presence of neural tube defects in the fetus ^(9,10) . The TubeNeurale is the structure from which the skull, brain and spinal cord are formed; normally it closes around the thirtieth day of conception and if this does not happen part of the brain or spinal cord remain uncovered and the fetus undergoes serious malformations such as: anencephaly, cephalocele or spina bifida. Daily intake of folic acid during pregnancy has been shown to reduce the occurrence of central nervous system abnormalities by 50-70%. Folic acid is not produced by the body, but is taken with food. A complete and balanced diet is usually sufficient for the daily requirement of this substance. Foods that contain folic acid are green leafy vegetables (salad, spinach, broccoli), ilegumi, liver, some types of fruit, yeast, milk and cereals. However, it is advisable not to cook fruit and vegetables because cooking eliminates about 90% of the content of this substance. The demand for folic acid increases when cell growth is very active, such as during pregnancy and breastfeeding, but also in other particular conditions (intake of particular drugs, alcoholism, insulin-dependent diabetes, celiac disease, leukemia). The recommended daily dose of folic acid under normal conditions is 0.2 mg and 0.4 mg during pregnancy. In particular, in this last case, this quantity is difficult to reach with a balanced diet and for this reason a folacin supplement is recommended during pregnancy, which should start the month before conception and continue for 2-3 months. In recent years, numerous studies have shown that the intake of folic acid, together with other vitamins of group B, is able to significantly reduce the levels of homocysteine.Homocysteine is an amino acid derived from methionine and its metabolism is closely related to the presence of folic acid and vitamin B12. A deficit in these metabolic pathways determines an excess production of homocysteine which is exported into the bloodstream and therefore a state of hyperhomocysteinemia. This condition is multifactorial and may be due to genetic factors and to the assumption of some pharmacological therapies (not modifiable) or to food or lifestyle factors such as unbalanced diet, smoking, excessive consumption of alcoholic beverages or coffee (modifiable). It has recently been hypothesized that hyperhomocysteinemia may be a risk factor for cardiovascular pathologists through various mechanisms: direct action on the endothelium with an atherogenic effect; action on platelets, as a pro-coagulant factor; action on lipoproteins ⁽¹¹⁾ . However, it is not yet clear whether and how the reduction of the levels of this amino acid can actually decrease the cardiovascular risk ^(12,13) . Hyperhomocysteinemia, especially when associated with low folic acid levels, appears to be dangerous even during pregnancy for correct fetal development ^(14,15) , and for pregnancy success ⁽¹⁶⁾ , and appears to be involved in the development of osteoporosis. favoring its appearance ⁽¹⁷⁾ . It has been shown that the intake of folic acid together with other B vitamins (B12 and B6) is able to significantly reduce the levels of homocysteine in the blood ^(12,18-20) .

Vitamin B12

Vitamin B12 (cobalamin) is a water-soluble vitamin belonging to the group of vitamins B which is also called cobalamin because it has a cobalt atom at the center of its atomic structure. It is absorbed in the intestine, thanks to the link with the "intrinsic factor" protein which binds to it in the duodenum. Once in circulation, it detaches from intrinsic factor and associates with two other proteins that transport it to target tissues. Its main function is to participate in the synthesis of DNA and its deficiency appears mainly at the level of highly proliferative tissues such as the hematopoietic tissue from which red blood cells originate. In fact, lack of vitamin B12 (and / or folic acid) can be responsible for megaloblastic anemia even if the etiology of this pathology is multifactorial. In fact, a deficit in these two factors determines a defect in DNA synthesis also in red blood cells, interfering with their normal proliferation and maturation and thus causing the formation of excessively large, oval-shaped cells containing immature nuclei ⁽²¹⁾ . Furthermore, vitamin B12 plays an essential role in maintaining the integrity of the nervous system by intervening in the synthesis of myelin, the sheath that protects neurons ⁽²²⁾ . Vitamin B12 is taken with the diet and the foods that contain it are of animal origin: meat, poultry, egg yolks, fish, fermented cheeses and milk powder. For this reason, those who adopt a vegetarian diet must pay particular attention to their diet to ensure that they cover the daily requirement of this protein which in the average adult varies from 2 to 6 micrograms. Deficiencies of this vitamin are quite rare and are due either to a poor intake through the diet or to problems with poor absorption of the vitamin itself. Prolonged vitamin B12 deficiency over time can lead to progressively increasing anemia, weakness, paleness, jaundice, fatigue, tingling in the extremities, reduced perception of pain, irritability, headache, depression, decreased mental ability, disturbed balance, sleep. Taking vitamin B12 during pregnancy, along with folic acid, has been shown to aid in the natural development of the fetus ⁽²³⁾ . Another important function of vitamin B12 is to intervene in the metabolism of homocysteine. Homocysteine is an amino acid derived from methionine and its metabolism is closely related to the presence of folic acid and vitamin B12. A deficit in these metabolic pathways determines an excess production of homocysteine which is exported into the bloodstream and therefore a state of hyperhomocysteinemia. This condition is multifactorial and may be due to genetic factors and the intake of certain pharmacological therapies (not modifiable) or to dietary or lifestyle factors such as an unbalanced diet, smoking, excessive consumption of alcoholic beverages or coffee (modifiable). It has recently been hypothesized that hyperhomocysteinemia may be a risk factor for cardiovascular pathologies through various mechanisms: direct action on the endothelium with atherogenic effect; action on platelets, as a pro-coagulant factor; action on lipoproteins ⁽²⁴⁾ . However, it is not yet clear whether and how the reduction of thaleamino acid levels can actually decrease cardiovascular risk ^{. (25,26)} Hyperhomocysteinemia appears to be dangerous even during pregnancy, for correct fetal development ^(27,28) , and for the development of osteoporosis, favoring its onset ⁽²⁹⁾ . It has been shown that taking vitamin B12 together with other B vitamins (folic acid and B6) is able to significantly reduce homocysteine levels in the blood ^(25,30-32) .

Ingrediants

100 100 100 100

* LARN: recommended daily intake levels.

How to use

Take 2 sachets a day.
Dissolve the contents of the sachet directly in the mouth.

Warnings

Do not exceed the recommended daily dose.
Keep out of the reach of children under three years of age.
Supplements are not intended as a substitute for a varied diet.
For pregnant or lactating women and children it is recommended to consult the doctor's opinion.
The product contains sugar alcohols: excessive consumption can have laxative effects.

storage

Store the product in a cool, dry and protected from light.

Format

Pack with 40 sachets of 2g.