Relansia Drops Medic Italy 30ml

Relansia Drops Medic Italia based on Melatonin

Dietary supplement in drops that promotes the maintenance of a normal sleep and wakefulness rhythm and helps to control anxious states.

Crataegus Oxyacantha (hawthorn)

Common hawthorn (Crataegus oxyacantha) is a shrub that belongs to the Rosaceae family. It is a plant rich in flavonoids and procyanidins, powerful antioxidants. Among its various properties, the main actions exerted by the hawthorn are cardioprotective and sedative. Thanks to the high content of flavonoids, hawthorn exerts its powerful antioxidant action, and has been shown to be very useful in reducing oxidative stress during cardiac hyperfusion, thus exerting a cardioprotective effect (1-3).
Other studies have shown that hawthorn is able to alleviate symptoms in patients suffering from heart failure by increasing the flow and use of oxygen by the heart (4-6).
In addition, a slightly hypotensive effect has also been observed by flavonoids, although the mechanism is not yet well known. Recently it has been observed that a hawthorn extract is able to modify the sodium impermeability of cells and this ability could explain the effects observed both in vitro and in clinical studies (7-9). Finally, a slight bradycardising effect through the activation of the muscarinic receptor has been observed in in vivo studies and in clinical studies in the cardiovascular field (10, 11).
As for the sedative effect of hawthorn, it has been observed in animal models that its main action is carried out at the level of the central nervous system even if the mechanism of action is not yet clear. The flavonoids that are likely to bind to the central and peripheral receptors of benzodiazepines are probably involved and this would determine the anxiolytic and moderately hypnogenic effects observed. The efficacy and tolerability of the product has also been demonstrated by a clinical study conducted in patients with disturbed anxiety. In this case, the efficacy of the hawthorn-escolzia combination has been demonstrated in particular (12,13).
The intake of hawthorn is therefore particularly indicated in patients with sleep disturbances, showing a sedative and anxiolytic activity combined with a cardioprotective action particularly useful in patients in whom palpitation and tachycardia problems also occur.

Eschscholzia Californica (Escolzia or Papaverodella California)

Escolzia is a plant native to California and Mexico that belongs to the Papaveraceae family and its main component is glialcalodi. Its main action occurs at the level of the central nervous system and in fact it possesses hypno-inducing, sedative and anxiolytic properties that have been demonstrated in various scientific works and in clinical studies (1,2). An important quality of this plant is that it carries out its activity without causing stunning upon awakening; it also appears to be more active in women than men.
The efficacy and tolerability of the product was also demonstrated by a clinical study conducted in patients with anxiety disorders. In this case, the efficacy of the hawthorn-escolzia combination has been shown in particular (3). However, the mechanism of action that determines its effects has not yet been clarified. It has been hypothesized that the Escolzia extract can inhibit the enzymatic degradation of catecholamines and therefore keep their levels high, interfering with their metabolic pathways (4). In another study carried out it is hypothesized that there is an involvement of the benzodiazepine receptors that would be more activated (5). The intake of Escolzia is therefore particularly indicated in cases of insomnia and anxiety.

PassifloraIncarnata

Passiflora is a genus that includes about 465 species of annual perennial herbaceous plants, including Passiflora incarnata. It is used for medicinal purposes as it boasts sedative properties of the central nervous system, in particular anxiolytic and curative of insomnia, where it induces a sleep similar to the physiological one without nocturnal awakenings and with a morning awakening without dizziness. The leaves and aerial parts contain various active ingredients, including numerous flavonoids and alkaloids, the main responsible for the beneficial effects of this plant.
Numerous in vitro and in vivo studies have been carried out to clarify the mechanism of action of passionflower extracts (1).
It has been shown that the anxiolytic effect observed is mainly due to aiflavonoids, which are said to be able to bind to the GABA receptors for benzodiazepines, thus determining a significant sedative action, with the advantage, however, of not affecting alertness (2,3). In another research carried out on an animal model it has been shown that Passionflower seems to have anticonvulsant properties and also in this case flavonoids seem to be involved (4).
The properties of Passionflower have also been demonstrated in several clinical studies conducted on patients with sleep disorders and / or different levels of anxiety. Also from these studies it has emerged that the intake of Passionflower improves the quality of sleep (5) and is an effective treatment to control anxiety levels without the typical side effects of benzodiazepines such as light-headedness during the day (6,7). Thanks to this property, some studies have shown that the administration of passionflower is a useful pre-treatment in patients who must undergo surgery as it decreases the patient's level of anxiety without inducing sedation (8,9).
Finally, the armanic alkaloids contained in the plant have a spasmolytic action on the smooth muscles of the gastrointestinal tract and the uterus, thus making its intake indicated even in the case of menstrual pain and irritable bowel syndrome of nervous origin. The intake of Passionflower is therefore particularly effective in treating mild anxiety syndromes and sleep disorders and can also be a valuable aid in the case of menstrual pain and irritable bowel syndrome of nervous origin.

Melatonin

Melatonin is a natural hormone produced predominantly by the pineal gland which is secreted into the cerebrospinal fluid and into the bloodstream. It performs several functions but the main and also the best known concerns its role in regulating the sleep-wake rhythm. Its levels vary significantly during the day and reach its peak of maximum concentration during the night, between 24:00 and 03:00, while, on the contrary, during the day, its levels are very low, being sensitive to light ( 1.2). Numerous studies have shown that the level and amplitude of the period of secretion decrease with age (3-5).
Since melatonin plays a very important role in regulating sleep-wake cycle, dietary supplementation with this hormone has been found to be very effective in treating insomnia problems and in the treatment of jet lag. In particular, melatonin is indicated both for falling asleep disorders and for sleep interruption, improving the quality of rest, as emerged from several clinical studies (1, 6-10).
Furthermore, its effectiveness in alleviating sleep disorders that occur in the case of intercontinental flights, accelerating the adaptation of the body to the new sleep-wake cycle is now well documented (11-13). An important feature of this molecule is that it is non-addictive and has no major side effects typical of pharmacological sedatives. However, melatonin also appears to be involved in numerous other physiological processes, and in fact demonstrates excellent antioxidant activity and important immunomodulatory activity (14-16).
It is involved in the body's antioxidant system that protects molecules from damage caused by free radicals. It is able to act directly on highly toxic hydroxyl radicals with a “scavanger” or “scavenger” type action (17-19). It also stimulates the activity of numerous other antioxidant enzymes, such as glutathione reductates and glutathione peroxidase (20,21), and the synthesis of glutathione, another powerful antioxidant (14). A further important feature of this molecule is its ability to be both hydrophilic and lipophilic, which allows this molecule to reach almost all cellular compartments and therefore to exert its protective action at practically all levels (15).
As far as its activity on the immune system is concerned, melatonin has an immunostimulating action thanks to the presence of its receptors on leukocytes, both at the membrane level and at the nuclear level. It would thus be able to modulate the proliferative response of stimulated lymphocytes and, at the intracellular level, induce the production of cytokines (16).
As a consequence of all the functions in which it is involved, it has been hypothesized that the decrease in melatonin levels may be linked with the phenomenon of aging but the mechanism is still to be elucidated (14, 15). The intake of melatonin is therefore particularly suitable for treating sleep disorders and jet lag syndrome, also considering that the intake of this molecule will bring to the body an important protective effect at an antioxidant level, which will result in a general well-being for the organism.

It does not contain gluten.

Ingrediants

4 mg

How to use

Dilute with water.
Recommended dosage: 10 drops diluted in a glass of water to be taken twice a day after dinner and before bedtime.

Warnings

Do not exceed the recommended daily dose.
Keep out of the reach of children under three years of age.
Supplements are not intended as a substitute for a varied diet.
For pregnant or lactating women and children it is recommended to consult the doctor's opinion.

Format

30 ml bottle with dispenser.