RNE Biofarma

Raliprost Forte

Dietary supplement

Raliprost Forte and Raliprost

Packaging - Raliprost Forte: 20 sachets of 4 g
Recommended dosage : 1-2 sachets a day for at least 3-6 months of treatment to be repeated cyclically

Packaging - Raliprost: 30 tablets of 1300 mg
Recommended dosage : 1-2 tablets a day for at least 3-6 months of treatment to be repeated cyclically

Products based on Green Tea es (Camelia Sinensis, tit. 50% Catechins, 30% EGCG), Serenoa repens es (tit. 40-45% FFA), Soya es (tit. 40% isoflavones), Zinc, Lycopene, Turmeric longa es (tit. 95% curcuminoids), Vitamin E and Selenium (Present only in Raliprost Forte) which can be useful for naturally promoting the physiological functions of the male urinary tract, especially the prostate, and perform synergistically an antioxidant action for the prevention of cell damage induced by oxidative stress.

Composition

Green tea eg (Camelia Sinensis, tit. 50% Catechins, 30% EGCG)
The Catechins extracted from the leaves of green tea (Camelia sinensis) are plant metabolites belonging to the flavonoid family. They represent more than 80% of the polyphenols present in green tea and are mainly represented by:

Epigallocatechin 3-Gallate (EGCG)
Epigallocatechin (EGC)
Epicatechin 3-Gallate (ECG)
Epicatechin (EC)

although most of the biological effects are attributed to EGCG. In our body the catechins exert a high antioxidant action due to their structure characterized by a combination of aromatic rings and hydroxyl groups which allows them to neutralize free radicals and to strengthen and reactivate the other antioxidant systems. Epidemiological observation studies show that the intake of catechins is associated with a lower incidence of cardiovascular diseases, a decrease in total cholesterol levels, an improvement in blood circulation and blood pressure. The catechins also exert a photoprotective effect by reducing the damage induced by UV rays, and are able to promote the production of detoxifying enzymes in the liver, thus reducing the production of oxygen free radicals. Epidemiological observations also indicate that individuals who regularly consume green tea are subject to a lower risk of death from prostate cancer. In fact, the Chinese population who regularly consume this drink has a lower incidence of prostate cancer worldwide (5%).
Several studies conducted on cell culture systems and on animal models have demonstrated the usefulness of catechins in reducing the risk of prostate cancer, as they inhibit the growth of prostate cancer cell lines by inducing apoptosis of these cells.

Serenoa repens es (tit. 40-45% FFA)
It is a small broad-leaved palm with dark red berries native to the southern United States. The extract from its fruits contains fatty acids (a. Lauric, myristic, caprylic, palmitic, stearic, oleic, linoleic, linolenic), methyl and ethyl esters of fatty acids (beta-sitosterol, stigmasterol, campesterol, etc.), saturated alcohols and long-chain unsaturated, carotenoids, flavonoids (rutin, isoquercetin) and polysaccharides.
It has been shown that taking Serenoa repens is useful in problems related to the prostate, especially as an adjuvant in prostatitis and in the treatment of Benign Prostatic Hypertrophy (BPH) to counteract the disorders associated with it since it helps to regulate the poor and altered flow urinary typical of this pathology. The effectiveness of the extracts of Serenoa repens is given by the set of different mechanisms of action:

Selective antiandrogenic activity - It is expressed through the local selective antagonism of the link between dihydrotestosterone (DHT) and androgen receptor
Inhibition of 5-alpha reductase - Enzyme involved in the transformation of testosterone into dihydrotestosterone (DHT), an androgen hormone with a greater affinity for androgen receptors whose binding determines a stimulation of cell proliferation thus favoring the hypertrophy of the prostate tissue
Anti-inflammatory and anti-edema action - The flavonoid component induces a reduction in capillary permeability
Spasmolytic action - At the level of the muscles of the urinary tract it determines the reduction of the obstruction of the urethra
Antiestrogenic effect - Determined by a sharp decrease in estrogen receptors

Soya es (tit. 40% isoflavones)
They are heterocyclic phenols of plant origin with hormonal properties of the estrogenic type. Ubiquitous of the plant world, high concentrations are found above all in soy (soy isoflavones). Soy isoflavones constitute the phytoestrogens with greater estrogenic activity and are mainly represented by daidzein and genistein. Several studies have highlighted that soy isoflavones exert an estrogenic, anti-estrogenic, antioxidant and immunostimulating action, and stimulate the fibroblasts to produce hyaluronic acid and collagen thus preventing skin aging. For these multiple actions, phytoestrogens are used in multiple fields, especially for cardiovascular diseases, hypercholesterolemia, premenstrual syndrome, menopause, osteoporosis, neoplasms and to improve the effects of skin aging. Several epidemiological evidences also indicate their use in the prevention of prostate cancer. The Japanese population, in fact, who has a diet low in fat and rich in soy, has very high plasma concentrations of isoflavones and is subject to a lower incidence of prostate cancer and consequently to a lower mortality from this pathology. The suggested mechanism of action involves the adhesion of genistein to prostate cancer cells, the inhibition of the growth of these cells, and finally the induction of apoptosis. Isoflavones probably also exert a potent inhibitory activity of the enzyme 5-alpha reductase, which is implicated in the mechanisms of proliferation of prostate cells that are at the basis of the development of prostate cancer.

Zinc
Zinc is an essential element for the life of human beings. It is present in trace amounts in our body (from 1, 5 to 2.5 g) and its daily requirement is between 7 and 10 mg. Zinc intervenes in the beta chain of hemoglobin, is involved in the development of the gonads, in nervous functions and in memory. It is part of insulin, proteins with a zinc-finger structure and acts as a cofactor for the functioning of numerous enzymes, such as dehydrogenases, involved in the metabolism of nucleic acids, carbohydrate and lipid proteins, and also those with antioxidant action such as Superoxide Dismutase (SOD). Its deficiency therefore considerably affects body growth. It is mainly found in foods such as meat, nuts, egg yolk, mushrooms, cocoa even if its intestinal absorption does not exceed 30%.
Zinc is active above all in the mechanisms of protection against damage induced by free radicals. The interest in its use in the prevention of prostate cancer can be traced back to some studies in which a marked reduction of this element was found in prostate cancer cells compared to normal prostate cells. In healthy prostate tissue, Zinc acts as an inhibitor of the enzyme m-aconitase which takes part in the Krebs cycle. Lacking the inhibition caused by low zinc levels, malignant cells are able to freely complete the Krebs cycle by converting from low-efficiency epithelial cells to energy-efficient cells.

Lycopene
Lycopene is a non-polar acyclic compound, belonging to the carotenoid family and characterized by an open chain of 40 carbon atoms with 11 conjugated double bonds but, unlike beta-carotene, it is devoid of provitamin A activity, i.e. it is not transformed in the body in vitamin A, but it can be converted to beta-carotene by the action of beta-cyclase. It is present in high quantities in ripe tomatoes (Solanum lycopersicum - Fam. Solanaceae) and is also responsible for the red and yellow color characteristic of other fruits and vegetables. The lycopene content is influenced by the level of ripeness of the tomato: it has been calculated that in red and ripe tomatoes there are about 50 mg / kg of lycopene, while the concentration drops to 5 mg / kg in the yellow varieties.
Lycopene cannot be synthesized by our body, so its presence depends on the diet. An intake of 50-100 mg per day is recommended to benefit from its effects. Being a lipophilic substance, its absorption is related to the presence of fats in the diet, and once absorbed it is distributed in the tissues in correlation with the presence of lipids: in fact it is more abundant in the adipose tissue, in the testicles, in the seminal fluid, in the adrenal glands. , in the liver, prostate and breast.
By virtue of its acyl structure, its high hydrophobicity, the number of conjugated double bonds and the presence of two further double bonds compared to the other carotenoids, lycopene is a very interesting substance in relation to its multiple therapeutic applications. In fact, it has a very high antioxidant activity, protecting cells from aging and degenerative damage produced by free radicals, in an extremely more effective way than common carotenoids. Lycopene also shows a very effective antioxidant and repairing capacity, in particular in degeneration of the prostate, uterus and gastrointestinal system. Epidemiological observation studies have in fact reported that an abundant consumption of tomato and its derivatives or high concentrations of circulating lycopene are related to a reduction in the risk of onset of degenerative diseases of the digestive system (esophagus, stomach, colon, rectum and pancreas) and prostate.

Curcuma longa es (tit. 95% curcuminoids)
Curcuma is a genus of plants belonging to the Zingiberacee family, including numerous species including C. longa, C. aromatica and C. xanthorrhiza, used since ancient times both as spices (e.g. curry and ginger) and as medicinal herbs in the traditional Chinese and Indian medicine for the treatment of indigestion, intestinal disorders, hepatitis, diabetes, atherosclerosis and bacterial infections. The main bioactive compounds present in these plant species are curcuminoids, represented mainly by curcumin, which shows the greatest biological effects, without any significant side effects. Numerous studies have highlighted the remarkable anti-inflammatory, antioxidant, anticoagulant, antihypertensive, antidiabetic, antiviral, hepatoprotective and chemopreventive properties of curcumin. The anti-inflammatory activity is mediated by its ability to inhibit the enzymes involved in the inflammation process (e.g. cyclooxygenase-2, lipooxygenase) resulting in a down-regulation of the expression of various proinflammatory cytokines (TNF-α, IL-1, IL- 2, IL-6, IL-8, IL-12), which are very often closely related to the promotion of inflammatory and degenerative pathologies. The antioxidant activity of curcumin, which is expressed through the scavenging of oxygen free radicals, seems to be considerably higher (about 300 times) than that exercised by vitamin E. Curcuminoids are therefore a valid aid in the prevention of damage induced by ' excessive oxidative stress at the level of the epithelial cells of the uro-genital tract.

Vitamin E
It is a fat-soluble vitamin essential for humans, present in animal and vegetable fats and oils. It plays an important antioxidant role in preventing the lipid peroxidation process and the oxidation of cellular constituents, caused by the action of free radicals. In synergy with Vitamin C it also protects the skin from the harmful action of UV rays. Furthermore, a study called ATBC (Alpha-Tocopherol, Beta-Carotene Cancer Prevention) has shown that the daily intake of Vitamin E reduces the risk of developing prostate cancer by 32%.

Selenium - Present only in Raliprost Forte -
Selenium is an important element involved in the protection of cells thanks to its ability to counteract the damage induced by free radicals. It acts mainly in association with the antioxidant enzyme glutathione peroxidase, which in turn works together with vitamin E in preventing the damage produced by free radicals to cell membranes.