Sametil - Supplement for Tiredness

Situations of particular psychological and physical stress, advancing age and a deficient diet can cause fatigue and mood alterations, characterized by a more or less intense psychological distress and a series of symptoms that can vary from one person to the other. The most frequently observed symptoms are: depressed mood, decreased interest in usual activities, decreased or increased appetite, altered sleep-wake rhythm, agitation, slowed movement, fatigue and unjustified lack of energy, decreased concentration and 'intellectual efficiency in study and at work, irritability and unmotivated crying. The most accredited scientific theory, which attempts to explain the genesis of mood disorders, supports the idea that in some subjects with genetic predisposition and in particular psychological conditions there is a deficit in the synthesis and turnover of some brain neurotransmitters such as serotonin, dopamine and noradrenaline.

Sametil is a food supplement consisting of a group of functional substances that are physiologically present in our body. The active ingredients contained in it contribute to promoting the mood through the modulation of the synthesis of some neurotransmitters, and contribute to normal psychological function. Levo Methylfolate, S-Adenosyl-L-Methionine, and some B vitamins such as Riboflavin B2, Pyridoxine B6 and Cyanocobalamin B12, act so that L-Tryptophan can be converted first into serotonin and then into melatonin, and L- Tyrosine can be converted first to dopamine and then to norepinephrine.

Characteristics of functional principles

Sulfo-Adenosil-Levo-Metionina : S-Adenosyl-L-Methionine, also known as SAMe or Ademetionine, is an amino acid physiologically present in the tissues and fluids of the body, being a donor of methyl groups it promotes Transmethylation Reactions, through which it facilitates the synthesis of serotonin, dopamine, adrenaline. and norepinephrine. In childhood and adolescence, the levels of S-Adenosyl-L-Methionine are elevated, they decrease significantly in adults and are further reduced in the elderly. People with mood disorders have a low concentration of S-Adenosyl-L-Methionine in the cerebrospinal fluid. Following oral administration, S-Adenosyl-L-Methionine crosses the blood-brain barrier, increases its concentration in brain tissue and cerebrospinal fluid and expresses antidepressant activity. Both L-Methylfolate and Group B vitamins are essential co-factors in the metabolism and restoration of S-Adenosyl-L-Methionine.

L-Tryptophan : Tryptophan is an essential amino acid. Levo-Tryptophan is the biologically active form. It intervenes in numerous chemical reactions, in particular it represents the biological substrate necessary for the synthesis of serotonin. The main derivative of serotonin is melatonin, physiologically produced by the pineal gland. Melatonin is a pseudo-hormone capable of modulating the often altered sleep-wake rhythms in subjects with mood disorders. The absorption and bioavailability of tryptophan is slowed down by the other amino acids and for this reason it is best to take it on an empty stomach.

L-Tyrosine : Tyrosine is a polar amino acid. Levo-Tyrosine is the biologically active form. It represents the biological substrate necessary for the synthesis of dopamine, noradrenaline and adrenaline. Following the intake of L-Tyrosine, an increase in the blood levels of these neurotransmitters is observed, with favorable effects on mood. This effect is more observable in subjects subjected to conditions of psychophysical stress.

L-Methylfolate : In recent years, observational studies have highlighted a relationship between mood disorders and a folate deficiency. The biochemical mechanisms through which folates influence mood disorders involve transmethylation reactions in the metabolism of monoamine neurotransmitters and melatonin. Levo-Methylfolate (6S-5-Methyl-THF) is a natural folate that makes up 98% of the folate present in human plasma. Bioavailability studies have shown that supplementation with methylfolate is as effective as that with folic acid in improving folate levels in the body. Unlike folic acid, methylfolate does not need to be biotransformed as it is already the active form, and its intake does not involve the presence of non-metabolized forms in the blood, therefore methylfolate is not affected by functional polymorphisms in the MTHFR and DHFT genes, which instead they condition the effectiveness of folic acid.

Vitamins of Group B : Riboflavin, Pyridoxine, Cyanocobalamin. The Vitamins of Group B contained in Sametil are Riboflavin (Vit.B2), Pyridoxine (Vit.B6), and Cyanocobalamin (Vit.B12). These water-soluble vitamins protect brain functions through energy metabolism that leads to the formation of ATP and the metabolism of biogenic amines that influence mood. Low levels of these vitamins are also associated with low levels of S-Adenosyl-L-Methionine. The intake of B2, B6, B12 and L-Methylfolate reduces the plasma level of homocysteine, a molecule associated with mood disorders, especially in subjects with folic acid metabolism disorders (genetic polymorphism of the enzyme MTHFR).

Indications

Sametil integrates physiological nutritional elements that contribute to normal psychological function, to the reduction of tiredness and fatigue and to a normal mood.

Dosage and method of use

1 tablet per day unless otherwise prescribed. To improve the absorption of the active ingredients, it is recommended to take the tablets between meals.

Format

Pack of 20 gastro-resistant tablets of 1g.