Tris-NAC

Sterile Solution For Dogs And Cats

Description
Sterile solution.
Tris-EDTA + N-Acetyl Cysteine (NAC) buffer with high hygienic strength for dogs and cats.

Tris-EDTA (Ethylene Diammin Tetracetic Acid) has bactericidal activity on non-growing bacteria located within the biofilm ( Ciofu et al, 2017 ); in association with Tromethamine (Tris) it damages the walls of bacterial cells and increases the penetration inside the bacterial membranes; it is well tolerated and non-ototoxic; acts in synergy with chlorhexidine ( Guardabassi et al, 2010 ). Recently, in vitro work has shown that Tris-EDTA is a more than effective support in the treatment of chronic cases of Pseudomonas otitis with the presence of potential biofilm combined with antibiotics ( Pye et al, 2014 ).

NAC is an N-acetylated derivative of the amino acid cysteine, it has a mucolytic action, therefore it destroys the production of exopolysaccharides thus weakening the EPS matrix. It has recently been used in eight clinical studies as an adjuvant treatment to destroy mature biofilm and prevent its formation and has demonstrated an excellent safety and efficacy profile.

The association of Tris-EDTA and NAC on the skin and in the ear before the application of topical products such as chlorhexidine, antibiotics, synthetic antimicrobial peptides, therefore allows an increase in the permeability of the mature biofilm and, consequently, its disintegration. , effectively supporting the overcoming of the problem of resistance to the classic antibacterial therapeutic approach.

How to use
1. Press on the top of the bottle until the cap is completely broken.
2. Shake the bottle.
3. With the syringe found inside the package, take the quantity to be used according to the instructions of the Veterinarian.
In the ear canal: adequately spray and massage at the base of the ear.
On the skin: spray until the affected area is completely soaked.
Repeat the treatment as needed or as instructed by the veterinarian.

Format
120 ml bottle.

Code PP3310001