Sterile medical device for intravesical instillations intended to form a protective and waterproof barrier which favors the natural restoration of the surface integrity of the urothelium altered by dysmetabolic situations associated with inflammatory noxae of various origins. The presence of Adelmidrol favors the restoration of the physiological level of palmitoylethanolamide in the bladder interstitium, decreased by the inflammatory phenomenon resulting from the progressive loss of control of the normal regulation of the endo-bladder mast cells. In this way, the phenomenon of depolymerization of hyaluronic acid, both instilled and naturally present in the urothelium, is controlled, on which the ability of the polysaccharide to restore the superficial integrity of the urothelium depends. Therefore, the association of hyaluronic acid and Adelmidrol determines a synergistic effect capable of restoring the superficial integrity of the urothelium altered by dysmetabolic situations associated with inflammatory noxae of various origins.

Components
Bottle: Adelmidrol (INN), sodium hyaluronate, sodium chloride, disodium edetate, phosphate buffer 10 mM pH 7.0, water to 50 ml.

How to use
One intravesical instillation every 7 days or as directed by the doctor. It is recommended to handle the devices that make up the Vessilen Kit only after having washed your hands thoroughly and to take all possible precautions in order to reduce the risk of product contamination. Wait for the bladder to empty spontaneously, insert a sterile catheter into the bladder and wait for the bladder to empty completely. Withdraw the sterile solution from the glass bottle with the supplied disposable syringe and needle. Remove the needle from the syringe. Connect the supplied sterile, disposable Luer-Lock Adapter to the syringe. Connect the Luer-Lock Adapter to the catheter and instill all the solution contained in the syringe into the bladder.

Warnings
Catheter instillation of Vessilen should be performed by competent medical personnel using a probe, syringe or cannula. Vessilen is a disposable medical device. Do not sterilize again, do not reuse unused portions of solution, do not use if the package is open or damaged as the sterility of the product is compromised. Reuse of the device could lead to risks of patient contamination. There are no known side effects of the product if used according to the instructions provided by the manufacturer. There are currently no known interactions between Vessilen and medicines normally used in the reference pathologies. The product is not suitable for subjects already sensitized to the components present in the formulation. Stop the treatment in case of any undesirable effect. Keep out of the sight and reach of children. Do not use after the expiration date.

storage
Keep in a cool and dry place.
Validity with unopened package : 36 months.

Format
The kit contains:
- 50 ml bottle;
- 50 ml syringe (Luer-Lock Adapter needle);
- Catheter adapter.

Code 6210