Z-Yal

CE Medical Device.
Humectant and lubricating ophthalmic solution based on hyaluronic acid sodium salt 0.2%.
Thanks to its chemical-physical properties, hyaluronic acid adheres perfectly to the corneal surface and thus allows a profitable hydration and lubrication. Hyaluronic acid is of biotechnological origin and of high molecular weight such as to give it high adhesion power and long residence time in contact with the cornea. It represents the ideal remedy in case of dryness due to varifactors such as stress, dust, fumes, prolonged exposure to sunlight, continuous work at video terminals, use of contact lenses.

Composition
Sodium hyaluronate 0.2%; monobasic sodium phosphate monohydrate; sodium phosphate dibasicododecahydrate; sodium chloride; EDTA disodium bidrate; WFI water.

Instructions for Use
Apply 1- 2 drops per eye.
It is possible to repeat the operation several times a day according to need.

Warnings
The product is for external ophthalmic use only.
Do not use in case of known incompatibility with any component of the preparation.
Do not use the product after the expiry date indicated on the package.
Do not store above 25 ° C.
Keep the preparation out of the reach of children.

Format
Bottle of 10 ml.

Bibliography
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- Snlbson GR, Greaves JL, Soper ND, Prjdal JI, wilson CG, BranAJ. Precorneal residence time of sodium hyaluronate solutions studie by quantitativegamma scintigraphy. Eye. 1990; 4: 594-602.
- Shimmura S, Ono M, Shinozaki K, Toda i, Takamura E, Mashima Y, Tsubota K. Sodium hyaluronate eyedrops in the tratments of dry eye. Br J Ophthalmol. 1995; 79 (11): 1007-1011.
- Aragona P, Micali A, Paladino G, Ferrari F, Puzzolo D. Effects of tear substitute on conjunctival epithelium of mice. Ophthalmic Res. 2007; 39 (5): 265-75. Epub 2007 Sep.12. PubMed PMID: 17851267.
- Milazzo G, Papa V, Aragona P, Russa S, Russa P, Di Bella A. Effectiveness of sodium hyaluronate eye drops of different osmolarities in the symptomatictreatment of dry eye patients. Adv Exp Med Biol. 2002; 506 (Pt B): 1233-5. PubMed PMID: 12614058.
- Aragon P, Di Stefano G, Ferrare F, Spinella R, Stila A. SodiumHyaluronate eye drops of different osmolarity for the treatment of dry eye in Slogren'ssyndrome patients. Br J Ophthalmol. 2002 Aug; 86 (8): 879-84. PubMed PMID: 12140209; PubMedCentral PMCID: PMC1771217.
- Aragon P, Papa V, Micali A, Santocomo M, Milazzo G. long termtreatment with sodium hyaluronate-contayning artificial tears reduces ocular surfaceclamage in patients whyt dry eye. Br J Ophthalmol. 2002 Feb; 82 (2): 181-4. PubMed PMID: 11815344; PubMed Central PMCID: PMC1771021.
- Papa V, Aragona P, Russa S, Di Bella A, Russa P, Milazzo G. Comparison of hypotonic and isotonic solutions containing sodium hyaluronate on thesympyomatic tratment of dry eye patients. Ophthalmologia. 2001 Mar Apr; 215 (2): 124-7.PubMed PMID: 11244343.